116895-09-1

Basic information

• Product Name: 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE
• Synonyms: 2-Amino-6-chloro-4-(diethylamino)pyrimidine;2,4-pyrimidinediamine, 6-chloro-N~4~,N~4~-diethyl-;N4,N4-diethyl-6-chloro-pyrimidine-2,4-diyldiamine;6-chloro-N~4~,N~4~-diethylpyrimidine-2,4-diamine(SALTDATA: FREE);(2-amino-6-chloro-pyrimidin-4-yl)-diethyl-amine;6-chloro-N',N'-diethyl-pyrimidine-2,4-diamine;6-chloro-N',N'-diethylpyrimidine-2,4-diamine;BAS 06504417
• CAS NO: 116895-09-1
• Molecular Formula: C8H13ClN4
• Molecular Weight: 200.67
• Mol File: 116895-09-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 395.4 °C at 760 mmHg
• Flash Point: 192.9 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 1.85E-06mmHg at 25°C
• Refractive Index: 1.6
• PKA: 3.96±0.10(Predicted)
• CAS DataBase Reference: 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE(116895-09-1)
• EPA Substance Registry System: 6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE(116895-09-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 116895-09-1(Hazardous Substances Data)

Usage

General Description

6-CHLORO-N4,N4-DIETHYLPYRIMIDINE-2,4-DIAMINE, also known as Chloroethylamine, is a chemical compound with the molecular formula C7H14ClN5. It is a pyrimidine derivative that is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. This chemical has two ethyl groups attached to the nitrogen atoms and a chlorine atom attached to the carbon atom in the pyrimidine ring. It is widely used in the pharmaceutical and agricultural industries due to its versatile reactivity and ability to participate in various chemical reactions. The compound is also an important intermediate in the production of anticancer drugs and can be used as a raw material for the synthesis of other biologically active compounds.

InChI:InChI=1/C8H13ClN4/c1-3-13(4-2)7-5-6(9)11-8(10)12-7/h5H,3-4H2,1-2H3,(H2,10,11,12)

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 109-89-7 diethylamine 

Relevant articles and documents

Investigation of novel pesticides with insecticidal and antifungal activities: Design, synthesis and SAR studies of benzoylpyrimidinylurea derivatives

In order to find pesticides with insecticidal and antifungal activities, a series of novel benzoyl pyrimidinylurea derivatives were designed and synthesized. All target compounds were identified by 1H-NMR spectroscopy and HRMS. Insecticidal and antifungal activity of these compounds were evaluated and the structure-activity relationships (SAR) were clearly and comprehensively illustrated. Compound 7, with low toxicity to zebrafish (LC50 = 378.387 μg mL?1) showed 100% inhibition against mosquito (Culex pipiens pallens) at 0.25 μg mL?1. Both compounds 19 and 25 exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 13 phytopathogenic fungi), which were better than those of the commercial pesticide pyrimethanil (>50% inhibitory activities against eight phytopathogenic fungi). Furthermore, compounds 19 and 25 exhibited protective activity against Sclerotinia sclerotiorum on leaves of Brassica oleracea L. during in vivo experiments.

CHEMICAL COMPOUNDS

The invention is directed to to substituted indazole derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 - R6 and X are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of disorders characterized by constitutively activated ACG kinases such as cancer and more specifically leukemia and cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.