116922-72-6

Basic information

• Product Name: (4-fluoro-3-pyridyl)phenylmethanone
• Synonyms: (4-fluoro-3-pyridyl)phenylmethanone
• CAS NO: 116922-72-6
• Molecular Weight: 201.2
• Mol File: 116922-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-fluoro-3-pyridyl)phenylmethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluoro-3-pyridyl)phenylmethanone(116922-72-6)
• EPA Substance Registry System: (4-fluoro-3-pyridyl)phenylmethanone(116922-72-6)

Safety Data

• Hazardous Substances Data: 116922-72-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 694-52-0 4-fluoropyridine 
• 116922-65-7 (4-fluoro-3-pyridyl)phenylmethanol 

Downstream Products

• 116922-81-7 10-phenyl-6,7,8,9-tetrahydrobenzo<1,6>naphthyridine 
• 3810-12-6 (4-aminopyridin-3-yl)(phenyl)methanone 
• 116922-77-1 (4-methylamino-3-pyridyl)phenylmethanone 

Relevant articles and documents

Directed Lithiation of 4-Halopyridines: Chemoselectivity, Regioselectivity and Application to Synthesis

4-Chloro and 4-fluoropyridines were ortho-lithiated by n-butyllithium-TMEDA chelate or lithium diisopropylamide at low temperature.The resulting 3-lithio 4-halopyridines were reacted with electrophiles which led to various 3,4-disubstituted pyridines.The versatility of this functionalization is enhanced by the 4-halogen reactivity towards nucleophiles such as water, methylate and amines.Some of the 3,4-disubstituted synthons were annelated to naphthyridine, xanthone and coumarin or condensed to Hantzsch-ester or to "chlotrimazol" analogues.Lithiation of 4-fluoropyridine led in one step to 3,4-pyridyne, which was trapped by cycloaddition with furans.