116986-08-4

Basic information

• Product Name: Methyl 2-(broMoMethyl)nicotinate
• Synonyms: Methyl 2-(broMoMethyl)nicotinate;3-Pyridinecarboxylic acid, 2-(broMoMethyl)-, Methyl ester
• CAS NO: 116986-08-4
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.05862
• Mol File: 116986-08-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 291.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.533±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.40±0.22(Predicted)
• CAS DataBase Reference: Methyl 2-(broMoMethyl)nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(broMoMethyl)nicotinate(116986-08-4)
• EPA Substance Registry System: Methyl 2-(broMoMethyl)nicotinate(116986-08-4)

Safety Data

• Hazardous Substances Data: 116986-08-4(Hazardous Substances Data)

Usage

General Description

Methyl 2-(bromomethyl)nicotinate is a chemical compound that's typically used in organic synthesis. It's a niche product in the chemical industry, primarily used for research purposes and in specialty reactions. Its IUPAC name is Methyl 2-[(bromomethyl)nicotinate] and the molecular formula is C7H6BrNO2. It is also known as Methyl 3-bromo-2-pyridinecarboxylate. It can be classified under different categories, such as pyridines, heterocyclics, or halides. It's considered hazardous and needs to be handled with caution due to its potentially reactive properties, maintaining safety protocols when in use.

Upstream product

• 65719-09-7 methyl 2-methylnicotinate 
• 38749-79-0 3-bromo-2-picoline 

Downstream Products

• 81452-47-3 methyl 2-tosylmethylnicotinate 
• 81452-44-0 2-(Toluene-4-sulfinylmethyl)-nicotinic acid methyl ester 
• 25230-59-5 methyl 2-formylnicotinate 
• 155058-02-9 7,8-Dihydro-1,6-Naphthyridine-5(6H)-one 
• 80957-68-2 5,6,7,8-tetrahydro-1,6-naphthyridine 
• 55942-61-5 2-(phenoxymethyl)pyridine-3-carboxylic acid 
• 259809-44-4 7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester 
• 1036381-91-5 tert‐butyl 2‐oxo‐1,5,7,8‐tetrahydro‐1,6‐naphthyridine‐6(2H)‐carboxylate 

Relevant articles and documents

INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS

Provided herein are compounds of formula (V) that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents

Aromatic aldehydes elicit their antisickling effects primarily by increasing the affinity of hemoglobin (Hb) for oxygen (O2). However, challenges related to weak potency and poor pharmacokinetic properties have hampered their development to treat sickle cell disease (SCD). Herein, we report our efforts to enhance the pharmacological profile of our previously reported compounds. These compounds showed enhanced effects on Hb modification, Hb-O2 affinity, and sickling inhibition, with sustained pharmacological effects in vitro. Importantly, some compounds exhibited unusually high antisickling activity despite moderate effects on the Hb-O2 affinity, which we attribute to an O2-independent antisickling activity, in addition to the O2-dependent activity. Structural studies are consistent with our hypothesis, which revealed the compounds interacting strongly with the polymer-stabilizing αF-helix could potentially weaken the polymer. In vivo studies with wild-type mice demonstrated significant pharmacologic effects. Our structure-based efforts have identified promising leads to be developed as novel therapeutic agents for SCD.

Azacycle diketone compound and preparation method thereof (by machine translation)

The invention provides a azacyclodiketone compound which is characterized by being a compound represented by the following structure. The compound has inhibitory activity on cap-dependent endonuclease. (by machine translation)