1169869-53-7

Basic information

• Product Name: C₂₂H₁₆ClN₃O₄
• CAS NO: 1169869-53-7
• Molecular Weight: 421.84
• Mol File: 1169869-53-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₆ClN₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₆ClN₃O₄(1169869-53-7)
• EPA Substance Registry System: C₂₂H₁₆ClN₃O₄(1169869-53-7)

Safety Data

• Hazardous Substances Data: 1169869-53-7(Hazardous Substances Data)

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 
• 62189-77-9 1-(4-chlorobenzoyl)indole-3-carbaldehyde 

Relevant articles and documents

Design, synthesis and anticancer activities of hybrids of indole and barbituric acids-Identification of highly promising leads

By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized. Evaluations of these molecules over 60 cell line panel of human cancer cells have identified two molecules with significant anticancer activities. Dockings of two active molecules in the active sites of COX-2, thymidylate synthase and ribonucleotide reductase indicate their strong interactions with these enzymes.