1170194-86-1Relevant articles and documents
Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors
Atobe, Masakazu,Maekawara, Naomi,Kawanishi, Masashi,Suzuki, Hiroko,Tanaka, Eiichi,Miyoshi, Shiro
, p. 2111 - 2116 (2013/05/08)
A series of 1,1-dioxothieno[2,3-d]isothiazole (thienosultam) derivatives were designed and synthesized as novel ADAMTS-5 inhibitors for an investigation into a side chain of thienosultam for the S1′ pocket. The resulting compounds (19 and 24) show high AD