1170318-71-4

Basic information

• Product Name: tert-butyl (4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)phenyl)carbamate
• Synonyms: tert-butyl (4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)phenyl)carbamate
• CAS NO: 1170318-71-4
• Molecular Weight: 366.417
• Mol File: 1170318-71-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)phenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)phenyl)carbamate(1170318-71-4)
• EPA Substance Registry System: tert-butyl (4-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)phenyl)carbamate(1170318-71-4)

Safety Data

• Hazardous Substances Data: 1170318-71-4(Hazardous Substances Data)

Upstream product

• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 1402230-94-7 2-[2-[2-[4-(tert-butoxycarbonylamino)phenoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 1402230-93-6 tert-butyl N-[4-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]phenyl]carbamate 
• 54840-15-2 4-N-tert-butoxycarbonylaminophenol 
• 36839-55-1 1,2-bis-(2-iodoethoxy)ethane 
• 178685-33-1 8-azido-3,6-dioxaoctyl tosylate 

Downstream Products

• 1170318-72-5 tert-butyl 4-(2-(2-(2-(4-((4-iodophenoxy)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)phenylcarbamate 

Relevant articles and documents

A novel cereblon modulator for targeted protein degradation

Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon (CRBN) and subsequently degrading IKZF1/3. Recently, their ability to recruit E3 ubiquitin ligase has been used in the proteolysis targeting chimera (PROTAC) technology. Herein, we design and synthesize a novel IMiD analog TD-106 that induces the degradation of IKZF1/3 and inhibits the proliferation of multiple myeloma cells in vitro as well as in vivo. Moreover, we demonstrate that TD-428, which comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1. Consequently, cell proliferation is inhibited due to suppressed C-MYC transcription. These results, therefore, firmly suggest that the newly synthesized IMiD analog, TD-106, is a novel CRBN modulator that can be used for targeted protein degradation.

SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Histone deacetylase (“HDAC”)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.