117068-45-8 Usage
Description
1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine, commonly known as HET-TP, is a thymidine analogue with an azido group. It serves as a potential building block for the synthesis of various nucleoside analogs and has been studied for its potential applications in nucleic acid labeling, bioconjugation, and drug development. The hydroxyethoxy group attached to the azidopropyl chain allows for efficient coupling reactions with other biomolecules, making it a valuable tool in chemical biology and biotechnology research. The thymine base also provides an opportunity for nucleic acid recognition and binding, presenting opportunities for drug targeting and delivery.
Uses
Used in Chemical Biology and Biotechnology Research:
1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine is used as a building block for the synthesis of nucleoside analogs for various applications in chemical biology and biotechnology research. The hydroxyethoxy group attached to the azidopropyl chain allows for efficient coupling reactions with other biomolecules, enhancing the compound's utility in these fields.
Used in Nucleic Acid Labeling:
1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine is used as a labeling agent for nucleic acids. Its unique structure enables efficient coupling with other biomolecules, making it a valuable tool for tracking and identifying specific nucleic acid sequences.
Used in Bioconjugation:
1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine is used as a bioconjugation agent, facilitating the attachment of various molecules to nucleic acids. This property is particularly useful in the development of targeted drug delivery systems and the creation of novel biocompatible materials.
Used in Drug Development:
1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine is used as a starting compound in the development of new drugs, particularly those targeting nucleic acids. The thymine base provides an opportunity for nucleic acid recognition and binding, which can be exploited for drug targeting and delivery.
Used in Drug Targeting and Delivery:
1-(1-(2-hydroxyethoxy)-3-azidopropyl)thymine is used as a targeting and delivery agent in the pharmaceutical industry. Its ability to recognize and bind to specific nucleic acid sequences makes it a promising candidate for the development of targeted drug delivery systems, potentially improving the efficacy and selectivity of therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 117068-45-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,0,6 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 117068-45:
(8*1)+(7*1)+(6*7)+(5*0)+(4*6)+(3*8)+(2*4)+(1*5)=118
118 % 10 = 8
So 117068-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N5O4/c1-7-6-15(10(18)13-9(7)17)8(19-5-4-16)2-3-12-14-11/h6,8,16H,2-5H2,1H3,(H,13,17,18)
117068-45-8Relevant articles and documents
Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition
Scheiner,Geer,Bucknor,Imbach,Schinazi
, p. 73 - 76 (2007/10/02)
An acyclic derivative of 3'-azido-3'-deoxythymidine, (R,S)-1-[1-(2-hydroxyethoxy)-3-azidopropyl]thymine (2), has been synthesized by a path involving Michael-type addition. Related thymidine analogues lacking the C(3')-C(4') bond were similarly obtained.
