117091-64-2 Usage
Description
Etoposide phosphate is a bioequivalent prodrug of the DNA topoisomerase II inhibitor Etoposide (E933750), which is a white crystalline powder. It is used in the treatment of a wide variety of hematological malignancies and solid tumors.
Uses
Used in Oncology:
Etoposide phosphate is used as an anticancer agent for the treatment of various hematological malignancies and solid tumors. It works by inhibiting the activity of DNA topoisomerase II, an enzyme essential for DNA replication and transcription, leading to the prevention of cancer cell growth and proliferation.
Used in Pharmaceutical Industry:
Etoposide phosphate is used as an active pharmaceutical ingredient in the formulation of the brand Etopophos, which is manufactured by Bristol-Myers Squibb. This brand is used for the treatment of cancer patients, providing an effective and convenient option for healthcare professionals and patients alike.
Check Digit Verification of cas no
The CAS Registry Mumber 117091-64-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,0,9 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117091-64:
(8*1)+(7*1)+(6*7)+(5*0)+(4*9)+(3*1)+(2*6)+(1*4)=112
112 % 10 = 2
So 117091-64-2 is a valid CAS Registry Number.
117091-64-2Relevant articles and documents
Efficient synthesis of the anticancer drug etoposide 4′-phosphate: Use of benzylic ether-protecting groups on the carbohydrate segment
Silverberg, Lee J.,Dillon, John L.,Vemishetti, Purushotham,Sleezer, Paul D.,Discordia, Robert P.,Hartung, Kerry B.,Gao, Qi
, p. 34 - 42 (2013/09/07)
The prodrug etoposide phosphate 2 is synthesized efficiently in three steps in 54.6% overall yield from 4′-demethylepipodophyllotoxin 3. The strategy pursued in the synthesis of 2 places the phosphate on 3 prior to coupling with the sugar and employs benzyl ether-protecting groups on both the phosphate and the sugar, allowing easy removal in one step. The importance of solvent, steric effects, and electronic effects in the coupling reaction is demonstrated. Two features of the synthesis are an unusual thermal anomerization of the carbohydrate component 5a and completely diastereoselective, one-pot crystallization of the coupled product 6a-β. The process has been demonstrated on multi-kilogram scale.
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
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, (2008/06/13)
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