117143-01-8Relevant articles and documents
Synthesis of Partial Structures of N-Glycopeptides Representing the Linkage Regions of the Transmembrane Neuraminidase of an Influenca Virus and of Factor B of the Human Complement System
Kunz, Horst,Waldmann, Herbert,Maerz, Joachim
, p. 45 - 50 (2007/10/02)
The synthesis of the protected N-chitobiosylasparaganine peptides 12a and 14, which correspond to the linkage regions of factor B of the human complement system and of the transmembrane neuraminidase of an influenza virus, was accomplished by applying the protecting group combination Boc group/allyl ester together with acetyl groups in the carbohydrate part.From 12a the allyl ester and the acetates were simultaneously removed using ammonia in methanol.The Boc group was cleaved without side reactions using anhydrous trifluoroacetic acid.Attempts to remove the Boc-protecting group from the glycopeptides already deblocked in the carbohydrate part resulted predominantly in the cleavage of the O-glycosidic bond.