1172127-44-4 Usage
Description
(S)-N-FMOC-alpha-Methyl-2-fluorophenylalanine, 98% ee, 98% is a non-natural, chiral amino acid derivative featuring a 9-fluorenylmethoxycarbonyl (FMOC) protecting group and a 2-fluorophenyl moiety. It is characterized by a high enantiomeric excess (98% ee) and purity (98%), making it a valuable building block for the synthesis of complex organic molecules and pharmaceutical compounds.
Used in Pharmaceutical Industry:
(S)-N-FMOC-alpha-Methyl-2-fluorophenylalanine, 98% ee, 98% is used as a reactant in the synthesis of non-natural macrocyclic and short hydrophobic peptides for the development of novel therapeutic agents with unique biological activities and selectivity.
Used in Peptide Synthesis:
(S)-N-FMOC-alpha-Methyl-2-fluorophenylalanine, 98% ee, 98% is used as a chiral building block for the synthesis of complex peptide-based structures, enabling the creation of innovative drugs with improved pharmacokinetic and pharmacodynamic properties.
Used in Organic Chemistry Research:
(S)-N-FMOC-alpha-Methyl-2-fluorophenylalanine, 98% ee, 98% is used as a versatile intermediate in organic chemistry research, allowing chemists to explore new synthetic routes and develop innovative methodologies for the preparation of biologically active compounds.
Used in Materials Science:
(S)-N-FMOC-alpha-Methyl-2-fluorophenylalanine, 98% ee, 98% can be employed as a monomer or building block in the development of novel materials with specific properties, such as self-assembling systems, supramolecular structures, or functional polymers with tailored characteristics for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1172127-44-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,2,1,2 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1172127-44:
(9*1)+(8*1)+(7*7)+(6*2)+(5*1)+(4*2)+(3*7)+(2*4)+(1*4)=124
124 % 10 = 4
So 1172127-44-4 is a valid CAS Registry Number.
1172127-44-4Relevant articles and documents
Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity
Mapelli, Claudio,Natarajan, Sesha I.,Meyer, Jean-Philippe,Bastos, Margarita M.,Bernatowicz, Michael S.,Lee, Ving G.,Pluscec, Jelka,Riexinger, Douglas J.,Sieber-McMaster, Ellen S.,Constantine, Keith L.,Smith-Monroy, Constance A.,Golla, Rajasree,Ma, Zhengping,Longhi, Daniel A.,Shi, Dan,Xin, Li,Taylor, Joseph R.,Koplowitz, Barry,Chi, Cecilia L.,Khanna, Ashish,Robinson, Gordon W.,Seethala, Ramakrishna,Antal-Zimanyi, Ildiko A.,Stoffel, Robert H.,Han, Songping,Whaley, Jean M.,Huang, Christine S.,Krupinski, John,Ewing, William R.
experimental part, p. 7788 - 7799 (2010/06/16)
Glucagon-like peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological regulation of glucose homeostasis and food intake. Herein, we report the discovery of a novel class of 11 amino acidGLP-1 receptor agonists. These peptides consist of a structurally optimized 9- mer, which is closely related to the N-terminal 9 amino acids ofGLP-1, linked to a substituted C-terminal biphenylalanine (BIP) dipeptide. SAR studies resulted in 11-mer GLP-1R agonists with similar in vitro potency to the native 30-mer. Peptides 21 and 22 acutely reduced plasma glucose excursions and increased plasma insulin concentrations in a mouse model of diabetes. These peptides also showed sustained exposures over several hours in mouse and dog models. The described 11-mer GLP-1 receptor agonists represent a new tool in further understanding GLP-1 receptor pharmacology that may lead to novel antidiabetic agents.
