1172590-91-8

Basic information

• Product Name: 1-allyl-3-hydroxy-3-(phenylethynyl)indolin-2-one
• Synonyms: 1-allyl-3-hydroxy-3-(phenylethynyl)indolin-2-one
• CAS NO: 1172590-91-8
• Molecular Weight: 289.334
• Mol File: 1172590-91-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-allyl-3-hydroxy-3-(phenylethynyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-allyl-3-hydroxy-3-(phenylethynyl)indolin-2-one(1172590-91-8)
• EPA Substance Registry System: 1-allyl-3-hydroxy-3-(phenylethynyl)indolin-2-one(1172590-91-8)

Safety Data

• Hazardous Substances Data: 1172590-91-8(Hazardous Substances Data)

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 830-74-0 1-allyl-1H-indole-2,3-dione 
• 932-88-7 1-iodo-2-phenylethyne 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Synthesis of 3-ethynyl-3-hydroxy-2-oxindoles and 3-hydroxy-3-(indol-3-yl) indolin-2-ones using CuWO4 nanoparticles as recyclable heterogeneous catalyst in aqueous medium

A simple method for the direct activation of phenyl acetylenes (spC-H activation) and selective synthesis of 3-hydroxy-3-(indol-3-yl) indolin-2-ones and 3,3′-bis(indolyl)indolin-2-ones (via Friedel-Crafts alkylation reaction) is reported in presence of Cu

Cycloisomerization of Oxindole-Derived 1,5-Enynes: A Calcium(II)-Catalyzed One-Pot, Solvent-free Synthesis of Phenanthridinones, 3-(Cyclopentenylidene)indolin-2-ones and 3-Spirocyclic Indolin-2-ones

Calcium-catalyzed regioselective synthesis of oxindole-derived 1,5-enynes, followed by cycloisomerization, from readily accessible 3-hydroxy-3-(alkynyl)indolin-2-ones and styrenes in one-pot, under solvent-free conditions is described. This method offers the synthesis of diverse molecules: phenanthridinones, 3-(cyclopentenylidene)indolin-2-ones, and 3-spirocyclic indolin-2-ones are obtained through cascade reactions including cross-dehydrative-coupling, [3,3]-sigmatropic rearrangement, carbocyclization, isomerization, oxidative-ring rearrangement, and Diels-Alder cycloaddition. In addition, this method features atom- and step-economy, broad substrate scope, and high yields. (Figure presented.).

Synthesis and bioactivity evaluation of 3-hydroxy-3-(phenylethynyl)indol-2- one analogues

A series of propargylic alcohol was synthesized by the addition of phenylacetylene to isatin and its N-substituted derivatives for the first time. This reaction involves activation of zinc reagent via coordination with carbonyl substrates that behave ''li