117309-43-0 Usage
Description
[Benzenesulfonyl-(4-methoxy-phenyl)-amino]-acetic acid is a chemical compound belonging to the class of benzenesulfonamides. It features a benzenesulfonyl group connected to a 4-methoxyphenylamino moiety, which is further linked to an acetic acid molecule. [Benzenesulfonyl-(4-methoxy-phenyl)-amino]-acetic acid holds potential in medicinal chemistry and pharmaceuticals due to its properties as a non-peptide angiotensin receptor antagonist, with possible anti-hypertensive and anti-fibrotic effects.
Uses
Used in Pharmaceutical Industry:
[Benzenesulfonyl-(4-methoxy-phenyl)-amino]-acetic acid is used as a non-peptide angiotensin receptor antagonist for its potential role in treating cardiovascular disorders and related conditions. Its ability to block angiotensin receptors may contribute to lowering blood pressure and reducing fibrosis, making it a promising candidate for drug development.
Used in Research and Development:
[Benzenesulfonyl-(4-methoxy-phenyl)-amino]-acetic acid serves as a valuable research tool for studying angiotensin receptor signaling pathways and related biological processes. Understanding these pathways can lead to the discovery of new therapeutic targets and the development of novel treatments for various diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [Benzenesulfonyl-(4-methoxy-phenyl)-amino]-acetic acid can be utilized for the synthesis of new compounds with potential therapeutic applications. Its unique structure and functional groups make it a versatile building block for designing and optimizing drug candidates targeting angiotensin receptors and other related molecular targets.
Check Digit Verification of cas no
The CAS Registry Mumber 117309-43-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,3,0 and 9 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 117309-43:
(8*1)+(7*1)+(6*7)+(5*3)+(4*0)+(3*9)+(2*4)+(1*3)=110
110 % 10 = 0
So 117309-43-0 is a valid CAS Registry Number.
117309-43-0Relevant articles and documents
N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase
DeRuiter, Jack,Borne, Ronald F.,Mayfield, Charles A.
, p. 145 - 151 (2007/10/02)
A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.
