117309-85-0

Basic information

• Product Name: [(2R,3R,4R,5R)-5-(4-amino-5-hexyl-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid
• CAS NO: 117309-85-0
• Molecular Formula: C₁₅H₂₆N₃O₈P
• Molecular Weight: 407.356
• Mol File: 117309-85-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 669°Cat760mmHg
• Flash Point: 358.4°C
• Density: 1.65g/cm³
• CAS DataBase Reference: [(2R,3R,4R,5R)-5-(4-amino-5-hexyl-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,3R,4R,5R)-5-(4-amino-5-hexyl-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid(117309-85-0)
• EPA Substance Registry System: [(2R,3R,4R,5R)-5-(4-amino-5-hexyl-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid(117309-85-0)

Safety Data

• Hazardous Substances Data: 117309-85-0(Hazardous Substances Data)

Usage

Description

[(2R,3R,4R,5R)-5-(4-amino-5-hexyl-2-oxo-pyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid, also known as tenofovir, is a nucleotide reverse transcriptase inhibitor derived from a modified nucleotide. It is characterized by its unique structure that allows it to interfere with the replication process of specific viruses. Tenofovir is known for its effectiveness in treating HIV and hepatitis B virus infections, making it a crucial component in the fight against these diseases.

Uses

Used in Pharmaceutical Industry:
Tenofovir is used as an antiviral agent for the treatment of HIV and hepatitis B virus infections. It works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of these viruses. By blocking this enzyme, tenofovir prevents the virus from replicating and spreading within the body, thus helping to manage and control the infection.
Used in HIV Treatment:
Tenofovir is used as a component of combination therapy for HIV patients. It is effective in suppressing the viral load and helping to rebuild the immune system, which is crucial for the overall health and well-being of individuals living with HIV.
Used in Hepatitis B Treatment:
In addition to its use in HIV treatment, tenofovir is also utilized in the treatment of hepatitis B virus infections. It helps to reduce the viral load and prevent the progression of the disease, which can lead to severe liver damage and other complications.
Used in Essential Medicines:
Tenofovir is considered an essential medicine by the World Health Organization and is included on the organization's list of essential medications for a basic health system. This highlights its importance in global health and the fight against HIV and hepatitis B virus infections.

Downstream Products

• 117309-93-0 5-n-hexylcytidine 3',5'-cyclic monophosphate ammonium salt