1173294-98-8

Basic information

• Product Name: (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone
• Synonyms: (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone
• CAS NO: 1173294-98-8
• Molecular Weight: 354.203
• Mol File: 1173294-98-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone(1173294-98-8)
• EPA Substance Registry System: (4-bromophenyl)(5-methoxy-2-(pyridin-2-yloxy)phenyl)methanone(1173294-98-8)

Safety Data

• Hazardous Substances Data: 1173294-98-8(Hazardous Substances Data)

Upstream product

• 4783-68-0 2-phenoxypyridine 
• 1122-91-4 4-bromo-benzaldehyde 
• 108-95-2 phenol 
• 109-04-6 2-bromo-pyridine 
• 99-90-1 para-bromoacetophenone 
• 7099-87-8 4-bromophenylglyoxylic acid 

Relevant articles and documents

Palladium-catalyzed direct ortho aroylation of 2-phenoxypyridines with aldehydes and catalytic mechanism investigation

A direct ortho aroylation of 2-phenoxypyridines with aldehydes leading to aryl ketones by the use of palladium(II) acetate, tert-butyl hydroperoxide, and chlorobenzene as the catalyst, oxidant, and solvent, respectively, is presented. Intra- and intermolecular kinetic isotope effects, radical trapping, and controlled experiments were carried out to support the proposed catalytic mechanism for the reaction. Syntheses of (2-hydroxyphenyl)(phenyl)methanones and 1-hydroxy-9H-fluoren-9-ones directed from ortho-aroylated 2-phenoxypyridines were demonstrated.

Palladium-catalyzed acylation of sp2 C-H bond: Direct access to ketones from aldehydes

A palladium-catalyzed direct access to ketones from aldehydes via C-H cleavage of arenes is described. The procedure utilizes air as a clean and free terminal oxidant.