117357-15-0

Basic information

• Product Name: 4-ethylphenyl 4-methylbenzenesulfonate
• Synonyms: 4-ethylphenyl 4-methylbenzenesulfonate
• CAS NO: 117357-15-0
• Molecular Formula: C₁₅H₁₆O₃S
• Molecular Weight: 276.35074
• Mol File: 117357-15-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-ethylphenyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethylphenyl 4-methylbenzenesulfonate(117357-15-0)
• EPA Substance Registry System: 4-ethylphenyl 4-methylbenzenesulfonate(117357-15-0)

Safety Data

• Hazardous Substances Data: 117357-15-0(Hazardous Substances Data)

Upstream product

• 123-07-9 4-Ethylphenol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 644-08-6 4-Methylbiphenyl 
• 5707-44-8 4-ethylbiphenyl 

Relevant articles and documents

METAL OXIDE CATALYZED RADIOFLUORINATION

Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1 : 1 acetonitrile- thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.

Nickel(0)-catalyzed cross-coupling of alkyl arenesulfonates with aryl Grignard reagents

The nickel-catalyzed cross-coupling reactions of neopentyl arenesulfonates with arylmagnesium bromides, involving nucleophilic aromatic substitution of alkyloxysulfonyl groups by aryl nucleophiles, take place in high yields. Optimal efficiencies are obtained by adding 3 + 2 equiv of the Grignard reagent to a mixture of dppfNiCl2 and the sulfonate in refluxing THF. Neopentyl arenesulfonates are useful sources of the electrophilic aryl groups in these transition metal-catalyzed cross-coupling reactions. Aryl sulfonates are inappropriate due to their ambident reactivity under the reaction conditions. This new cross-coupling reaction can be used for the creative elimination of alkyloxysulfonyl groups from aromatic compounds and for the preparation of unsymmetric terphenyls and oligophenyls.