1174-96-5Relevant articles and documents
Synthesis and cytotoxicity of podophyllotoxin analogues modified in the A ring
Castro, Angeles,Del Corral, Jose M. Miguel,Gordaliza, Marina,Grande, Concepcion,Gomez-Zurita, Antonia,Garcia-Gravalos, Dolores,San Feliciano, Arturo
, p. 65 - 74 (2003)
Several podophyllotoxin derivatives lacking the methylenedioxy group or with different functionalization of the A-ring of the cyclolignan skeleton have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549,
Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents
Terada,Fujimoto,Nomura,Yamashita,Kobunai,Takeda,Wierzba,Yamada,Yamaguchi
, p. 2720 - 2727 (2007/10/02)
Various podophyllotoxin derivatives from desoxypodophyllotoxin (DPT) were synthesized to examine the structural relationships between the biological significance (cytotoxic effect, effects on DNA topoisomerase II and tubulin polymerization) in vitro and a