1174047-27-8

Basic information

• Product Name: C₁₄H₈BrFN₂O₂
• Synonyms: C₁₄H₈BrFN₂O₂
• CAS NO: 1174047-27-8
• Molecular Weight: 335.132
• Mol File: 1174047-27-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₈BrFN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₈BrFN₂O₂(1174047-27-8)
• EPA Substance Registry System: C₁₄H₈BrFN₂O₂(1174047-27-8)

Safety Data

• Hazardous Substances Data: 1174047-27-8(Hazardous Substances Data)

Upstream product

• 405224-22-8 2-hydroxy-3-cyano-5-bromopyridine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 

Downstream Products

• 1174047-18-7 C₁₄H₈BrFN₂O₂ 

Relevant articles and documents

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype

This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype. This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and the first example of a mode of pharmacology 'switch' to provide PAMs with a non-MPEP scaffold.