117407-47-3

Basic information

• Product Name: Bis(t-butyl) 2-iodo-3,4,5-trimethoxybenzylpropanedioate
• Synonyms: Bis(t-butyl) 2-iodo-3,4,5-trimethoxybenzylpropanedioate
• CAS NO: 117407-47-3
• Molecular Weight: 522.377
• Mol File: 117407-47-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Bis(t-butyl) 2-iodo-3,4,5-trimethoxybenzylpropanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(t-butyl) 2-iodo-3,4,5-trimethoxybenzylpropanedioate(117407-47-3)
• EPA Substance Registry System: Bis(t-butyl) 2-iodo-3,4,5-trimethoxybenzylpropanedioate(117407-47-3)

Safety Data

• Hazardous Substances Data: 117407-47-3(Hazardous Substances Data)

Upstream product

• 64490-45-5 2-iodo-3,4,5-trimethoxybenzyl alcohol 
• 541-16-2 t-butyl malonate 
• 64490-46-6 2-Iodo-3,4,5-trimethoxybenzyl chloride 

Downstream Products

• 117370-36-2 bis(1,1-dimethylethyl) (E)-<<3,4,5-trimethoxy-2-<2-(trimethylsilyl)ethenyl>phenyl>methyl>propanedioate 

Relevant articles and documents

Cycloadditions of 4-pyrones. An approach to colchicine

The 4-pyrone, [5-acetoxy-4-oxo-4H-pyran-2-yl]carbonyl chloride was coupled with the malonate anion of bis(2,2,2-trichloroethyl) 2-ethenyl-3,4,5-trimethoxybenzylpropanedioate and analogs thereof. These adducts then underwent intramolecular thermal cyclizations (61-100% yield) to form the two fused seven member rings of the carbon skeleton of colchicine. The malonate moiety was deprotected and decarboxylated quantitatively to provide the desired ring system which contained a bridging ether, from C7a to C11 in the C ring, and a ketone at the 7 position. Removal of the bridging ether as H2O would yield the desired tropolone. Our attempts to remove the ether bridge were unsuccessful.