1174118-94-5

Basic information

• Product Name: (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane mono-(+)-di-O,O'-p-toluoyl-D-tartrate
• Synonyms: (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane mono-(+)-di-O,O'-p-toluoyl-D-tartrate
• CAS NO: 1174118-94-5
• Molecular Weight: 589.645
• Mol File: 1174118-94-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane mono-(+)-di-O,O'-p-toluoyl-D-tartrate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane mono-(+)-di-O,O'-p-toluoyl-D-tartrate(1174118-94-5)
• EPA Substance Registry System: (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane mono-(+)-di-O,O'-p-toluoyl-D-tartrate(1174118-94-5)

Safety Data

• Hazardous Substances Data: 1174118-94-5(Hazardous Substances Data)

Upstream product

• 646055-67-6 rac-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane 
• 32634-68-7 (2S,3S)-di-4-toluoyltartaric acid 

Relevant articles and documents

PREPARATION AND ENANTIOMERIC SEPARATION OF 7-(3-PYRIDINYL)-1,7-DIAZASPIRO[4.4] NONANE AND NOVEL SALT FORMS OF THE RACEMATE AND ENANTIOMERS

A novel scalable synthesis for the preparation of 7-(3- pyridinyI)- 1,7- diazaspiro[4.4)nonane has been developed, and7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane salts have been formed with succinic acid and oxalic acid. Additionally, 7-(3-pyridinyl)-1,7- diazaspiro[4.4]nonane has been separated into its stereoisomers via resolution with L and D di-p-toluoyltartaric acids, giving (R)- and (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane of high enantiomeric purity. Numerous solid salts of the resulting (R)- and (S)-7-(3-pyridinyl)-1,7- diazaspiro[4.4}nonane have been prepared. Methods for the preparation of the racemic and enantiomeric salts, pharmaceutical compositions comprising such salts, and uses thereof are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.