1174281-23-2

Basic information

• Product Name: pyridine-2,6-diyl bis(4-methylbenzenesulfonate)
• Synonyms: pyridine-2,6-diyl bis(4-methylbenzenesulfonate)
• CAS NO: 1174281-23-2
• Molecular Weight: 419.479
• Mol File: 1174281-23-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: pyridine-2,6-diyl bis(4-methylbenzenesulfonate)(CAS DataBase Reference)
• NIST Chemistry Reference: pyridine-2,6-diyl bis(4-methylbenzenesulfonate)(1174281-23-2)
• EPA Substance Registry System: pyridine-2,6-diyl bis(4-methylbenzenesulfonate)(1174281-23-2)

Safety Data

• Hazardous Substances Data: 1174281-23-2(Hazardous Substances Data)

Upstream product

• 626-06-2 2,6-dihydroxypyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 141-86-6 2.6-diaminopyridine 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 661464-60-4 N,N-bis((R)-2'-hydroxy-1'-phenylethyl)pyridine-2,6-dicarboxamide 
• 1242295-16-4 (4S,11S)-4,11-dimethyl-6,9-bis((S)-1-phenylethyl)-3,12-dioxa-6,9,18-triazabicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene 

Relevant articles and documents

A Novel Convenient Synthesis of Pyridinyl and Quinolinyl Triflates and Tosylates via One-Pot Diazotization of Aminopyridines and Aminoquinolines in Solution

The first effective and simple method for the direct one-pot transformation of 2-, 3-, and 4-aminopyridines, 2,6-diaminopyridines, and 2-aminoquinoline into the corresponding pyridinyl and quinolinyl trifluoromethanesulfonates and tosylates in solvents was developed. The procedure involves diazotization of the heterocyclic amines with sodium nitrite in mixed hexane-DMSO or hexane-DMF solutions in the presence of trifluoromethanesulfonic acid or p-toluenesulfonic acid.

Heteroaromatic tosylates as electrophiles in regioselective Mizoroki-Heck-coupling reactions with electron-rich olefins

Heteroaromatic 2-pyridyl tosylates were successfully applied as electrophiles in palladium(0)-catalyzed Mizoroki-Heck-coupling reactions to electron-rich olefins with complete aregioselectivity. This protocol represents a general strategy for the application of pyridyl tosylates and mesylates in the Mizoroki-Heck coupling. The catalytic system also proved adaptable to changes in the heteroaromatic core as well as large-scale applications. Finally, the synthetic utility of the functionalized α-heteroarylvinyl amides was established providing straightforward access to highly functionalized heteroaromatic compounds including chiral benzylic amide derivatives.