1174327-78-6

Basic information

• Product Name: (2-chlorophenyl)(4-methoxyphenyl)methanol
• Synonyms: (2-chlorophenyl)(4-methoxyphenyl)methanol
• CAS NO: 1174327-78-6
• Molecular Weight: 248.709
• Mol File: 1174327-78-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-chlorophenyl)(4-methoxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chlorophenyl)(4-methoxyphenyl)methanol(1174327-78-6)
• EPA Substance Registry System: (2-chlorophenyl)(4-methoxyphenyl)methanol(1174327-78-6)

Safety Data

• Hazardous Substances Data: 1174327-78-6(Hazardous Substances Data)

Upstream product

• 5720-07-0 4-methoxyphenylboronic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 54118-74-0 2-chloro-4'-methoxybenzophenone 

Relevant articles and documents

Highly Enantioselective Cobalt-Catalyzed Hydroboration of Diaryl Ketones

A highly enantioselective cobalt-catalyzed hydroboration of diaryl ketones with pinacolborane was developed using chiral imidazole iminopyridine as a ligand to access chiral benzhydrols in good to excellent yields and ee. This protocol could be carried out in a gram scale under mild reaction conditions with good functional group tolerance. Chiral biologically active 3-substituted phthalide and (S)-neobenodine could be easily constructed through asymmetric hydroboration as a key step.

The carbonyl group tuned electron-deficient phosphorus ligands and their application in Rhodium catalyzed arylation to aldehydes

Acylphosphines, which could be efficiently prepared from acid chlorides and secondary phosphines, were developed as a type of carbonyl group tuned electron-deficient phosphorus ligand. They were found to be a kind of efficient ligand in Rhodium catalyzed arylation to aldehydes through accelerating the transmetalation process. Chiral acylphosphine ligands could be generated from carboxylic acids bearing the chiral framework correspondingly.

CuII-catalyzed asymmetric hydrosilylation of diaryl- and aryl heteroaryl ketones: Application in the enantioselective synthesis of orphenadrine and neobenodine

With certain amounts of sodium tert-butoxide and tert-butanol as additives, catalytic amounts of an inexpensive and easy-to-handle copper source Cu(OAc)2·H2O, a commercially available and air-stable non-racemic dipyridylphosphine ligand, as well as the stoichiometric desirable hydride donor polymethylhydrosiloxane (PMHS), formed a versatile in situ catalyst system for the enantioselective reduction of a broad spectrum of prochiral diaryl and aryl heteroarylketones in air, in high yields and with good to excellent enantioselectivities (up to 96 %). In particular, the practical viability of this process was evinced by its successful applications in the asymmetric synthesis of optically enriched potent antihistaminic drugs orphenadrine and neobenodine. Copyright