1174495-37-4Relevant articles and documents
Development of a Practical Synthesis of the Progesterone Receptor Antagonist 4-{[3-Cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy}-2,6- dimethylbenzo-nitrile
Bradley, Paul A.,De Koning, Pieter D.,Johnson, Patrick S.,Lecouturier, Yann C.,McManus, David J.,Robin, Aurelie,Underwood, Toby J.
, p. 848 - 853 (2009)
The development and implementation of a scaleable process for the manufacture of the nonsteroidal progesterone receptor antagonist 8 is described. Key aspects of the synthesis include (i) a telescoped chlorination- etherification sequence to prepare diket
