1174638-38-0

Basic information

• Product Name: N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine
• Synonyms: N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine
• CAS NO: 1174638-38-0
• Molecular Weight: 406.462
• Mol File: 1174638-38-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine(1174638-38-0)
• EPA Substance Registry System: N-benzyl-N-4-toluenesulfonyl-4-methoxy-phenylethynylamine(1174638-38-0)

Safety Data

• Hazardous Substances Data: 1174638-38-0(Hazardous Substances Data)

Upstream product

• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 86440-77-9 1-bromo-2-(3-nitrophenyl)acetylene 
• 444681-65-6 1,1-dibromo-2-(3-nitrophenyl)ethene 

Relevant articles and documents

Keteniminium-Driven Umpolung Difunctionalization of Ynamides

A three-component Pd-catalyzed coupling of ynamides, aryl diazonium salts, and aryl boronic acids for the synthesis of novel triaryl-substituted enamides is described. This transformation represents the first example of an umpolung regioselective unsymmetrical syn-1,2-diarylation/aryl-olefination of ynamides. The aryl moieties of the diazonium salt (electrophile) and boronic acid (nucleophile) are explicitly incorporated in the electrophilic α- and nucleophilic β-position, respectively, of the ynamide, resulting in a single isomer of the N-bearing tetrasubstituted olefin. The scope is broad (68 examples), showing excellent functional-group tolerance. DFT calculations substantiate the rationale of the mechanistic cycle and the regioselectivity. The chemoselectivity and synthetic potential of the enamide products were also studied.

Copper-mediated coupling of 1,1-dibromo-l-alkenes with nitrogen nucleophiles: A general method for the synthesis of ynamides

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