1174638-55-1Relevant articles and documents
Synthesis of a 3,4-Dihydro-1,3-oxazin-2-ones Skeleton via an Intermolecular [4 + 2] Process of N-Acyliminium Ions with Ynamides/Terminal Alkynes
Han, Xiao-Li,Nie, Xiao-Di,Chen, Zhao-Dan,Si, Chang-Mei,Wei, Bang-Guo,Lin, Guo-Qiang
, p. 13567 - 13578 (2020/11/13)
An approach to access functionalized 3,4-dihydro-1,3-oxazin-2-ones has been developed by reacting semicyclic N,O-acetals 5 and 6 with ynamides 7 or terminal alkynes 8 in a one-pot fashion. The reaction went through a formal [4 + 2] cycloaddition process to generate a number of functionalized 3,4-dihydro-1,3-oxazin-2-ones 9a-9ak and 10a-10bc in yields of 34-97%. In addition, the utility of this transformation was demonstrated by the synthesis of (±)-sedamine 13.
Copper-mediated coupling of 1,1-dibromo-l-alkenes with nitrogen nucleophiles: A general method for the synthesis of ynamides
Coste, Alexis,Karthikeyan, Ganesan,Couty, Francois,Evano, Gwilherm
supporting information; experimental part, p. 4381 - 4385 (2009/10/23)
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