1174709-11-5Relevant articles and documents
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors
Boschelli, Diane H.,Wang, Daniel,Prashad, Amar S.,Subrath, Joan,Wu, Biqi,Niu, Chuan,Lee, Julie,Yang, Xiaoke,Brennan, Agnes,Chaudhary, Divya
body text, p. 3623 - 3626 (2010/04/26)
The key intermediate, 4-chloro-5-iodo-3-pyridinecarbonitrile, allowed for ready optimization of the PKCθ inhibitory activity of a series of 3-pyridinecarbonitriles. Analog 13b with a 4-methylindol-5-ylamino group at C-4 and a 4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl group at C-5 had an IC50 value of 7.4 nM for the inhibition of PKCθ.
Substituted Cyanopyridines as protein kinase inhibitors
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Page/Page column 24, (2008/06/13)
The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
