1174735-48-8Relevant articles and documents
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones
de Vicente, Javier,Hendricks, Robert T.,Smith, David B.,Fell, Jay B.,Fischer, John,Spencer, Stacey R.,Stengel, Peter J.,Mohr, Peter,Robinson, John E.,Blake, James F.,Hilgenkamp, Ramona K.,Yee, Calvin,Adjabeng, George,Elworthy, Todd R.,Tracy, Jahari,Chin, Elbert,Li, Jim,Wang, Beihan,Bamberg, Joe T.,Stephenson, Rebecca,Oshiro, Connie,Harris, Seth F.,Ghate, Manjiri,Leveque, Vincent,Najera, Isabel,Pogam, Sophie Le,Rajyaguru, Sonal,Ao-Ieong, Gloria,Alexandrova, Ludmila,Larrabee, Susan,Brandl, Michael,Briggs, Andrew,Sukhtankar, Sunil,Farrell, Robert,Xu, Brian
scheme or table, p. 3642 - 3646 (2010/03/31)
A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar potenc
