117507-85-4

Basic information

• Product Name: 4β-azido-4'-dimethyl-4-deoxy-epipodophyllotoxin
• Synonyms: 4β-azido-4'-dimethyl-4-deoxy-epipodophyllotoxin
• CAS NO: 117507-85-4
• Molecular Weight: 425.398
• Mol File: 117507-85-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4β-azido-4'-dimethyl-4-deoxy-epipodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-azido-4'-dimethyl-4-deoxy-epipodophyllotoxin(117507-85-4)
• EPA Substance Registry System: 4β-azido-4'-dimethyl-4-deoxy-epipodophyllotoxin(117507-85-4)

Safety Data

• Hazardous Substances Data: 117507-85-4(Hazardous Substances Data)

Upstream product

• 518-28-5 podofilox 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 16477-16-0 4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin 

Downstream Products

• 118139-42-7 4β-amino-4'-dimethyl-4-deoxy-epipodophyllotoxin 

Relevant articles and documents

HUMAN TOPOISOMERASE II-TARGETING ORGANOPLATINUM COMPOUNDS

Some organoplatinum compounds have been synthesized. These organoplatinum compounds are designed to be human Topoisomerase II-targeting drugs.

Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives

In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC50 values of 0.17 and 0.29 μM and TI values of 466.9 and 354.5, respectively.

New compounds related to podophyllotoxin and congeners: synthesis, structure elucidation and biological testing.

4-Azido, 4-amino, 4-amido and 4-alkoxy compounds related to the lignans podophyllotoxin and 4'-demethylepipodophyllotoxin have been synthesized, and their structures elucidated. The Ritter reaction was shown to be useful in the preparation of the 4-amido compounds with the required stereochemistry. A preparative method for 4-chloro-4-deoxypicrophyllotoxin, for which all earlier synthetic attempts resulted in the two dehydrated compounds, alpha- and beta-apopicropodophyllotoxin, was developed. Supplementary preliminary studies of the biological activities of some of the compounds were performed. All compounds had pronounced inhibitory effect on the in vitro growth of human cervical cancer cells and TC-mouse cells with 4-amino-4-deoxypodophyllotoxin and 4-azido-4-deoxypodophyllotoxin showing the highest activity. Alkaline elution studies indicate that the toxicity of the 4'-demethoxy derivatives is due to protein-mediated DNA nicking. None of the compounds were found to have antiviral effect against herpes simplex type 2 (HSV-2), human immunodeficiency (HIV), and cytomegalovirus (CMV) in doses not toxic to the cells.