117661-73-1

Basic information

• Product Name: 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione
• Synonyms: 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione
• CAS NO: 117661-73-1
• Molecular Weight: 265.312
• Mol File: 117661-73-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione(117661-73-1)
• EPA Substance Registry System: 2-(2-o-Tolyl-ethyl)-isoindole-1,3-dione(117661-73-1)

Safety Data

• Hazardous Substances Data: 117661-73-1(Hazardous Substances Data)

Upstream product

• 22364-68-7 2-tolylmethylnitrile 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 85-44-9 phthalic anhydride 
• 55755-16-3 2-methylphenethylamine 

Relevant articles and documents

Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor α

Benzylphthalimide analogs (P1P's) and phenethylphthalimide analogs (P2P's) have been found to exhibit thalidomide-like activity on the production of tumor necrosis factor (TNF)-α by the human leukemia cell line, HL-60, stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA). Structure-activity relationships are discussed on the basis of the TNF-α production-enhancing activity. Benzylphthalimide (P1P-00) exhibited activity which is weaker than that of thalidomide, but introduction of a methyl group at the ortho-position of the benzyl moiety (P1P-10) resulted an increase to a level comparable with that of thalidomide. Phenethylphthalimide (P2P-00) is more potent than thalidomide, and its fluorinated derivative, 2-phenethyl-4,5,6,7-tetrafluoro- 1H-isoindole-1,3-dione (FP2P-00), exhibited potent activity at very low concentrations.