1176727-65-3

Basic information

• Product Name: N-tert-butyl-α-[3-(pyrid-1'-yl)phenyl]nitrone chloride
• Synonyms: N-tert-butyl-α-[3-(pyrid-1'-yl)phenyl]nitrone chloride
• CAS NO: 1176727-65-3
• Molecular Weight: 290.793
• Mol File: 1176727-65-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-tert-butyl-α-[3-(pyrid-1'-yl)phenyl]nitrone chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-butyl-α-[3-(pyrid-1'-yl)phenyl]nitrone chloride(1176727-65-3)
• EPA Substance Registry System: N-tert-butyl-α-[3-(pyrid-1'-yl)phenyl]nitrone chloride(1176727-65-3)

Safety Data

• Hazardous Substances Data: 1176727-65-3(Hazardous Substances Data)

Upstream product

• 137353-85-6 N-tert-butyl-α-(3-aminophenyl)nitrone 
• 4185-69-7 1-(2,4-dinitrophenyl)-pyridinium chloride 

Downstream Products

• 1176728-13-4 C₁₇H₂₂N₂O⁽¹⁺⁾*Cl^(1-) 

Relevant articles and documents

Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants

The generation of excess reactive oxygen species (ROS) in mitochondria is responsible for much of the oxidative stress associated with ageing (aging), and mitochondrial dysfunction is part of the pathology of neurodegeneration and type 2 diabetes. Lipophilic pyridinium ions are known to accumulate in mitochondria and this paper describes a general route for the preparation of nitrone-containing N-arylpyridinium salts having a range of lipophilicities, as potential therapeutic antioxidants. The compatibility of nitrones with the Zincke reaction is the key to their synthesis. Their trapping of carbon-centred radicals and the EPR spectra of the resulting nitroxides are reported.