117688-46-7

Basic information

• Product Name: N,N'-di-p-tolylpyrrolidine-1-carboximidamide
• Synonyms: N,N'-di-p-tolylpyrrolidine-1-carboximidamide
• CAS NO: 117688-46-7
• Molecular Weight: 293.412
• Mol File: 117688-46-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N'-di-p-tolylpyrrolidine-1-carboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-di-p-tolylpyrrolidine-1-carboximidamide(117688-46-7)
• EPA Substance Registry System: N,N'-di-p-tolylpyrrolidine-1-carboximidamide(117688-46-7)

Safety Data

• Hazardous Substances Data: 117688-46-7(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 10532-64-6 N-(4-methylphenyl)cyanamide 
• 106-49-0 p-toluidine 
• 5720-05-8 4-methylphenylboronic acid 
• 726-42-1 di-p-tolylcarbodiimide 

Relevant articles and documents

A General and Mild Copper(I)-Catalyzed Three-Component Reaction of Cyanamides, Amines, and Diaryliodonium Triflates

A highly efficient copper-catalyzed three-component reaction of cyanamides, amines, and diaryliodonium triflates was developed for the synthesis of guanidines. The mild reaction accommodates both aromatic and aliphatic amines and provides the products in good yields with good functional group tolerance. Moreover, it was demonstrated that C-H activation of the arenes could be realized for the direct preparation of guanidines.

Synthesis of acylguanidine analogues: inhibitors of ADP-induced platelet aggregation

Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino)(4-morpholinyl)methyl] urea] was active and represented the first example of a bis(acylguanidine) with possible antithrombotic activity. In order to develop a structure-activity relationship for this class of compounds, we synthesized a number of new bis(acylguanidines). These were tested in vitro, and several analogues were also active. Ex vivo testing revealed that compounds 22, 41, 58, and 70-73 were orally active in rats or guinea pigs.