117688-49-0

Basic information

• Product Name: N,N'-di-p-tolylmorpholine-4-carboximidamide
• Synonyms: N,N'-di-p-tolylmorpholine-4-carboximidamide
• CAS NO: 117688-49-0
• Molecular Weight: 309.411
• Mol File: 117688-49-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N'-di-p-tolylmorpholine-4-carboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-di-p-tolylmorpholine-4-carboximidamide(117688-49-0)
• EPA Substance Registry System: N,N'-di-p-tolylmorpholine-4-carboximidamide(117688-49-0)

Safety Data

• Hazardous Substances Data: 117688-49-0(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 726-42-1 di-p-tolylcarbodiimide 
• 5720-05-8 4-methylphenylboronic acid 
• 10532-64-6 N-(4-methylphenyl)cyanamide 
• 106-49-0 p-toluidine 

Downstream Products

• 117688-60-5 C₄₆H₅₈N₈O₄ 

Relevant articles and documents

Copper-catalyzed oxidative three-component synthesis of N, N′, N′-trisubstituted guanidines

A copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines has been developed. This operationally simple oxidative process, which is performed in the presence of K2CO3, a catalytic amount of CuCl 2·2H2O, bipyridine, and oxygen (1 atm), allows the rapid assembly of N,N′,N″-trisubstituted aryl guanidines.

Synthesis of acylguanidine analogues: inhibitors of ADP-induced platelet aggregation

Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino)(4-morpholinyl)methyl] urea] was active and represented the first example of a bis(acylguanidine) with possible antithrombotic activity. In order to develop a structure-activity relationship for this class of compounds, we synthesized a number of new bis(acylguanidines). These were tested in vitro, and several analogues were also active. Ex vivo testing revealed that compounds 22, 41, 58, and 70-73 were orally active in rats or guinea pigs.