117688-87-6

Basic information

• Product Name: Piperazine-1,4-dicarboxylic acid bis-(cyclohexyl-{[(E)-cyclohexylimino]-morpholin-4-yl-methyl}-amide)
• CAS NO: 117688-87-6
• Molecular Weight: 725.031
• Mol File: 117688-87-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Piperazine-1,4-dicarboxylic acid bis-(cyclohexyl-{[(E)-cyclohexylimino]-morpholin-4-yl-methyl}-amide)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine-1,4-dicarboxylic acid bis-(cyclohexyl-{[(E)-cyclohexylimino]-morpholin-4-yl-methyl}-amide)(117688-87-6)
• EPA Substance Registry System: Piperazine-1,4-dicarboxylic acid bis-(cyclohexyl-{[(E)-cyclohexylimino]-morpholin-4-yl-methyl}-amide)(117688-87-6)

Safety Data

• Hazardous Substances Data: 117688-87-6(Hazardous Substances Data)

Upstream product

• 4975-73-9 N,N'-dicyclohexyl-4-morpholine carboxamidine 
• 4858-84-8 1,4-bis(chlorocarbonyl)piperazine 

Relevant articles and documents

Synthesis of acylguanidine analogues: inhibitors of ADP-induced platelet aggregation

Routine screening of compounds for inhibition of ADP-induced platelet aggregation in vitro revealed that 1'-hexamethylenebis[3-cyclohexyl-3-[(cyclohexylimino)(4-morpholinyl)methyl] urea] was active and represented the first example of a bis(acylguanidine) with possible antithrombotic activity. In order to develop a structure-activity relationship for this class of compounds, we synthesized a number of new bis(acylguanidines). These were tested in vitro, and several analogues were also active. Ex vivo testing revealed that compounds 22, 41, 58, and 70-73 were orally active in rats or guinea pigs.