1177347-71-5

Basic information

• Product Name: 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carbonitrile
• Synonyms: 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carbonitrile
• CAS NO: 1177347-71-5
• Molecular Weight: 262.274
• Mol File: 1177347-71-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carbonitrile(1177347-71-5)
• EPA Substance Registry System: 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carbonitrile(1177347-71-5)

Safety Data

• Hazardous Substances Data: 1177347-71-5(Hazardous Substances Data)

Upstream product

• 38956-80-8 3-hydrazino-6-phenylpyridazine 
• 123-06-8 Ethoxymethylenemalononitrile 

Downstream Products

• 1177295-20-3 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carboxylic acid amide 

Relevant articles and documents

Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives

Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.