117759-81-6Relevant articles and documents
Synthetic elaboration of N-substituents in thioamides
Katritzky, Alan R.,Denisko, Olga,Lang, Hengyuan
, p. 8703 - 8710 (2007/10/02)
N-(Benzotriazol-1-ylmethyl)arylthioamides, readily prepared from arylthioamides, formaldehyde and benzotriazole, undergo lithiation followed by reactions with alkyl halides, aldehydes and ketones to introduce the expected N-substituents into the N-methylene group. Subsequent displacements of the benzotriazolyl group by Grignard reagents, alkoxide or thioalkoxide anions provide general access to a wide variety of N-substituted thioamides in good yields.