117810-61-4

Basic information

• Product Name: N-ForMyl Desloratadine
• Synonyms: N-ForMyl Desloratadine;8-Chloro-6,11-dihydro-11-(1-formyl-4-piperidin ylidene)-5H-benzo[5,6]cyclohepta[1,2-b] pyridine
• CAS NO: 117810-61-4
• Molecular Formula: C20H19ClN2O
• Molecular Weight: 338.83066
• Product Categories: Amines;Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 117810-61-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 147-149 °C
• Boiling Point: 543.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.323±0.06 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), DMSO (Very Slightly), Methanol (Slightly, Sonicated)
• PKA: 4.17±0.20(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: N-ForMyl Desloratadine(CAS DataBase Reference)
• NIST Chemistry Reference: N-ForMyl Desloratadine(117810-61-4)
• EPA Substance Registry System: N-ForMyl Desloratadine(117810-61-4)

Safety Data

• Hazardous Substances Data: 117810-61-4(Hazardous Substances Data)

Usage

Description

N-ForMyl Desloratadine is an impurity found in Desloratadine (D290250), which is a nonsedating-type histamine H1-receptor antagonist. It is a pharmaceutical compound that is used in the treatment of various allergic conditions.

Uses

Used in Pharmaceutical Industry:
N-ForMyl Desloratadine is used as an impurity in the production of Desloratadine, a nonsedating antihistamine medication. It is utilized for its role in the treatment of allergic symptoms such as itching, runny nose, and watery eyes. The presence of N-ForMyl Desloratadine in Desloratadine is important to monitor and control, as it can affect the safety, efficacy, and quality of the final drug product.

Upstream product

• 100643-71-8 descarboethoxyloratadine 
• 109-94-4 formic acid ethyl ester 
• 32998-95-1 N-tert-butyl-3-methylpyridine-2-carboxamide 
• 31255-57-9 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile 
• 107285-30-3 3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide 
• 130642-50-1 {3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone 
• 79794-75-5 loratadine 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 38092-89-6 N-methyldesloratadine 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Highly Efficient and Selective N-Formylation of Amines with CO2 and H2 Catalyzed by Porous Organometallic Polymers

The valorization of carbon dioxide (CO2) to fine chemicals is one of the most promising approaches for CO2 capture and utilization. Herein we demonstrated a series of porous organometallic polymers could be employed as highly efficient and recyclable catalysts for this purpose. Synergetic effects of specific surface area, iridium content, and CO2 adsorption capability are crucial to achieve excellent selectivity and yields towards N-formylation of diverse amines with CO2 and H2 under mild reaction conditions even at 20 ppm catalyst loading. Density functional theory calculations revealed not only a redox-neutral catalytic pathway but also a new plausible mechanism with the incorporation of the key intermediate formic acid via a proton-relay process. Remarkably, a record turnover number (TON=1.58×106) was achieved in the synthesis of N,N-dimethylformamide (DMF), and the solid catalysts can be reused up to 12 runs, highlighting their practical potential in industry.

Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies.

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6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use

Derivatives of 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.