117830-21-4

Basic information

• Product Name: 1-Piperidinebutanamine, 4-(diphenylmethylene)-
• CAS NO: 117830-21-4
• Molecular Formula: C22H28N2
• Molecular Weight: 320.478
• Mol File: 117830-21-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Piperidinebutanamine, 4-(diphenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinebutanamine, 4-(diphenylmethylene)-(117830-21-4)
• EPA Substance Registry System: 1-Piperidinebutanamine, 4-(diphenylmethylene)-(117830-21-4)

Safety Data

• Hazardous Substances Data: 117830-21-4(Hazardous Substances Data)

Upstream product

• 50706-57-5 4-(diphenylmethylene)piperidine 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 

Downstream Products

• 124502-71-2 7-Methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid [4-(4-benzhydrylidene-piperidin-1-yl)-butyl]-amide 
• 118420-64-7 (E)-N-[4-(4-Benzhydrylidene-piperidin-1-yl)-butyl]-3-pyridin-3-yl-acrylamide 
• 123530-81-4 (E)-N-<4-(4-diphenylmethylene-1-piperidinyl)butyl>-3-(2-pyrazinyl)acrylamide 
• 117830-04-3 (E)-N-[4-(4-Benzhydrylidene-piperidin-1-yl)-butyl]-3-(6-methyl-pyridin-3-yl)-acrylamide 
• 123530-80-3 (E)-N-<4-(4-diphenylmethylene-1-piperidinyl)butyl>-3-(5-pyrimidinyl)acrylamide 
• 123530-79-0 (E)-N-<4-(4-diphenylmethylene-1-piperidinyl)butyl>-3-(3-pyridazinyl)acrylamide 

Relevant articles and documents

THIAZOLIDINECARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR THERAPEUTIC USES

Thiazolidinecarboxylic acid amides having combined antiallergic and antiasthmatic activities with an antagonist activity against platelet Activating Factor and having the following general formula (I) STR1

Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamides

A new series of 3-(3-pyridyl)acrylamides 16, 17, 19, and 26, and 5-(3-pyridyl)-2,4-pentadienamides 20-25 were prepared and evaluated for their antiallergic activity. Several of these compounds exhibited more potent inhibitory activities than the parent compounds 1a [(E)-N-[4 [4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acrylamide] against the rat passive cutaneous anaphylaxis (PCA) reaction and the enzyme 5-lipoxygenase. Particularly, 4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3-pyridyl)acrylamide (17p) showed an ED50 value of 3.3 mg/kg po in the rat PCA test, which was one-fifth of ketotifen and oxatomide. As compared with ketotifen and oxatomide, compound 17p (AL-3264) possessed a better balance of antiallergic properties due to inhibition of chemical mediator release, inhibition of 5-lipoxygenase, and antagonism of histamine.