117845-20-2Relevant articles and documents
Copper-catalyzed trifluoromethylation of terminal alkenes through allylic C-H bond activation
Xu, Jun,Fu, Yao,Luo, Dong-Fen,Jiang, Yuan-Ye,Xiao, Bin,Liu, Zhao-Jing,Gong, Tian-Jun,Liu, Lei
, p. 15300 - 15303 (2011/11/11)
An unprecedented type of reaction for Cu-catalyzed trifluoromethylation of terminal alkenes is reported. This reaction represents a rare instance of catalytic trifluoromethylation through C(sp3)-H activation. It also provides a mechanistically unique example of Cu-catalyzed allylic C-H activation/functionalization. Both experimental and theoretical analyses indicate that the trifluoromethylation may occur via a Heck-like four-membered-ring transition state.