1178863-99-4 Usage
Also known as
Ascomycin
Drug type
Semi-synthetic macrolide immunosuppressant
Used to treat
Atopic dermatitis (eczema)
Mechanism of action
Inhibits activation of T-lymphocytes and release of inflammatory cytokines
Derivative of
Pimecrolimus
Form
Acetylated form is more stable and has a longer half-life
Administration
Typically topically as a cream or ointment
Considered
Second-line treatment for atopic dermatitis
Efficacy
Improved with longer duration of action
Tolerability
Generally well-tolerated
Systemic absorption
Minimal
Side effects
Minimal
Check Digit Verification of cas no
The CAS Registry Mumber 1178863-99-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,8,8,6 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1178863-99:
(9*1)+(8*1)+(7*7)+(6*8)+(5*8)+(4*6)+(3*3)+(2*9)+(1*9)=214
214 % 10 = 4
So 1178863-99-4 is a valid CAS Registry Number.
1178863-99-4Relevant articles and documents
First chemoenzymatic synthesis of immunomodulating macrolactam pimecrolimus
Ferraboschi, Patrizia,Colombo, Diego,De Mieri, Maria,Grisenti, Paride
scheme or table, p. 4384 - 4388 (2009/10/26)
The preparation of pimecrolimus, a synthetic derivative of ascomycin endowed with immunomodulatory activity, requires the selective protection of 24-hydroxy group of the ascomycin, before elaboration of the 32-hydroxy group. The aim was achieved by means
