1178894-41-1

Basic information

• Product Name: 3-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
• Synonyms: 3-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione
• CAS NO: 1178894-41-1
• Molecular Weight: 562.581
• Mol File: 1178894-41-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione(1178894-41-1)
• EPA Substance Registry System: 3-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione(1178894-41-1)

Safety Data

• Hazardous Substances Data: 1178894-41-1(Hazardous Substances Data)

Upstream product

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 1178894-36-4 3-chloro-4-(6-fluoro-1-benzenesulfonyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione 

Downstream Products

• 1178894-46-6 3-(6-fluoro-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-b]pyridin-1-yl)-1H-pyrrole-2,5-dione 

Relevant articles and documents

Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

A series of novel 4-azaindolyl-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high potency to GSK-3β. Among them, compound 7c was the most promising GSK-3β inhibitor. Preliminary structure-activity relationships were discussed based on the experimental data obtained and showed that different substituents on the indole ring and side chains at 1-position of indole had varying degrees of influence on the GSK-3β inhibitory potency. In a cell-based functional assay, compounds 7c and 15a significantly reduced Aβ-induced Tau hyperphosphorylation by inhibiting GSK-3β.