1178977-12-2

Basic information

• Product Name: (S)-1,1-bis(4-methylphenyl)-2-(pyrrolidin-2-yl)ethanol
• Synonyms: (S)-1,1-bis(4-methylphenyl)-2-(pyrrolidin-2-yl)ethanol
• CAS NO: 1178977-12-2
• Molecular Weight: 295.425
• Mol File: 1178977-12-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1,1-bis(4-methylphenyl)-2-(pyrrolidin-2-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,1-bis(4-methylphenyl)-2-(pyrrolidin-2-yl)ethanol(1178977-12-2)
• EPA Substance Registry System: (S)-1,1-bis(4-methylphenyl)-2-(pyrrolidin-2-yl)ethanol(1178977-12-2)

Safety Data

• Hazardous Substances Data: 1178977-12-2(Hazardous Substances Data)

Upstream product

• 88790-37-8 (2S)-tert-Butyl 2-(2-methoxy-2-oxoethyl)pyrrolidine-2-carboxylate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 1338968-14-1 C₂₅H₃₃NO₃ 
• 259868-83-2 (S)-pyrrolidin-2-ylacetic acid methyl ester hydrochloride 

Relevant articles and documents

A systematic study of chiral homoprolinols and their derivatives in the catalysis of enantioselective addition of diethylzinc to aldehydes

Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the literature references, we have observed that the γ-amino alcohols are superior to the corresponding β-amino alcohols when the nitrogen and the oxygen are unsubstituted. Among the homoprolinols we tested, 2b gave the best results (45-88% yields, 44-81% ee) in the addition reactions. To the best of our knowledge, 2b has been noticed as one of the most efficient γ-amino alcohol catalysts based on pyrrolidine framework.