117902-96-2Relevant articles and documents
NEW SYTHESIS OF VASOPRESSIN AND ITS DE-9-GLYCINE ANALOGS
Panseuvich, O. S.,Chipens, G. I.,Korps, A. O.,Pavar, A. P.
, p. 370 - 375 (2007/10/02)
A unified scheme is proposed for the synthesis of vasopressin (I), de-9-glycinevasopressin (II), and de-9-glycinamidevasopressin (III) which has been developed on the basis of the tetrapeptide Glm-Asn-Cys(Bzl)-Pro and other homologous fragments of neurohypophyseal hormones as common initial and intermediate compounds.The free dithiols obtained by the reduction of protected derivatives of (I)-(III) by sodium in liquid ammonia have been oxidized to the corresponding cyclic disulfides (I)-(III) with the aid of 1 M H2O2 at 0-5 deg C and pH (8.5.The vasopressor activities of (I)-(III) a re, respectively 470 +/- 20, 1.7, and 0.5 IU/mg (rat, in vivo).
