117966-20-8

Basic information

• Product Name: 1-phenylsulfonyl-2-(5,6,7,8-tetrahydroisoquinolin-3-yl)-1H-indole
• Synonyms: 1-phenylsulfonyl-2-(5,6,7,8-tetrahydroisoquinolin-3-yl)-1H-indole
• CAS NO: 117966-20-8
• Molecular Weight: 388.49
• Mol File: 117966-20-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-phenylsulfonyl-2-(5,6,7,8-tetrahydroisoquinolin-3-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylsulfonyl-2-(5,6,7,8-tetrahydroisoquinolin-3-yl)-1H-indole(117966-20-8)
• EPA Substance Registry System: 1-phenylsulfonyl-2-(5,6,7,8-tetrahydroisoquinolin-3-yl)-1H-indole(117966-20-8)

Safety Data

• Hazardous Substances Data: 117966-20-8(Hazardous Substances Data)

Upstream product

• 184895-83-8 3-(indol-2-yl)-1-methylthio-5,6,7,8-tetrahydroisoquinoline 
• 117966-26-4 3-(1-(phenylsulfonyl)indol-2-yl)-1-methansulfonyl-5,6,7,8-tetrahydroisoquinoline 
• 98-09-9 benzenesulfonyl chloride 
• 26862-60-2 3-(indol-2-yl)-5,6,7,8-tetrahydroisoquinoline 

Downstream Products

• 117966-27-5 13-Benzenesulfonyl-8-hydroxy-2,3,4,7,8,13-hexahydro-1H-indolo[2',3':3,4]pyrido[1,2-b]isoquinolin-6-ylium; bromide 
• 47136-65-2 sempervirine 

Relevant articles and documents

Total synthesis of new indolo[2,3-a]quinolizine alkaloids sempervirine type, potential pharmaceuticals

Total synthesis of the two series of new pentacycilc cycloalk[g]indolo[2,3-a]quinolizine alkaloids (modified sempervirine possessing the wide range of activity), has been elaborated in five steps from 5-acetyl-3-methylthio-1,2,4-triazine (obtained from the simple acyclic materials). In the two key steps: inverse electron demand Diels-Alder reaction of precursor with cyclic enamines and the following Fischer indolization of 3-acetyl-1-methylthiocycloalka[c]pyridines, the AB-DE synthons, has been obtained. The final stages: desulfuration, and formation of the C-ring via the Gribble method have led to the expected zwitterionic alkaloids. Model syntheses of the indolopyridocoline and its methoxy analogue from 2-acetylpyridine have been performed for investigation of the microwave-induced Fischer synthesis of sensitive indoles and for obtaining compounds for comparative study of spectroscopic data.