117979-25-6

Basic information

• Product Name: N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine
• Synonyms: N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine
• CAS NO: 117979-25-6
• Molecular Formula: C₁₀H₁₀N₄
• Molecular Weight: 186.2132
• Mol File: 117979-25-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine(117979-25-6)
• EPA Substance Registry System: N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine(117979-25-6)

Safety Data

• Hazardous Substances Data: 117979-25-6(Hazardous Substances Data)

Upstream product

• 584-13-4 4-amino-1,2,4-triazole 
• 98-86-2 acetophenone 

Downstream Products

• 117979-32-5 (E,E)-N-<3-(dimethylamino)-1-phenyl-2-propenylidene>-4H-1,2,4-triazol-4-amine 
• 55054-92-7 6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine 

Relevant articles and documents

Synthesis and study of N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl) amine, N'-(4H-1,2,4-triazol-4-yl)benzamidine, and cobalt(ii), nickel(ii), and copper(ii) complexes based on these ligands

Methods were developed for the synthesis of complexes of CoII, NiII, and CuII nitrates and chlorides with N-(1-phenylethylidene)-N-(4H-1,2,4-triazol-4-yl)amine (L1) and N-(4H-1,2,4-triazol-4-yl)benzamidine (Lsu

Inhibiteurs mixtes des voies de la cyclooxygenase et des lipoxygenases: synthese et activite de derives hydrazoniques

Dual inhibitors of the cyclooxygenase and lipoxygenase pathways: synthesis and activity of hydrazone derivatives.Non-steroidal anti-inflammatory drugs (NSAIDs) act by preventing prostaglandin production.In recent years, research on non-steroid dual inhibitors of prostaglandin and leukotriene biosyntheses has been developed.These compounds should represent a new class of anti-inflammatory drugs, with a wider spectrum of activity than classical NSAIDs.The present paper reports the synthesis of hydrazone derivatives.The effect of various substitutions is studied on platelet cyclooxygenase (i.e. prostaglandin synthesis) and on leukocyte 5-lipoxygenase (i.e. leukotriene synthesis).Among the 50 tested compounds, 2 hydrazone derivatives were selected for their significant dual inhibitory potency: 2-acetylthiophene-2-thiazolylhydrazone 5g, and N-phenyl benzimidrazone 6c.Keywords - non-steroidal anti-inflammatory drugs / hydrazones / dual inhibitor / cyclooxygenase / lipoxygenase