1180491-92-2Relevant articles and documents
Synthesis and reactivity of gold(III) complexes containing cycloaurated iminophosphorane ligands
Kilpin, Kelly J.,Henderson, William,Nicholson, Brian K.
, p. 3669 - 3676 (2009)
Transmetallation reactions of ortho-mercurated iminophosphoranes (2-ClHgC6H4)Ph2P{double bond, long}NR with [AuCl4]- gives new cycloaurated iminophosphorane complexes of gold(III) (2-Cl2AuC6H4)Ph2P{double bond, long}NR [R = (R,S)- or (S)-CHMePh, p-C6H4F, tBu], characterised by NMR and IR spectroscopies, ESI mass spectrometry and an X-ray structure determination on the chiral derivative R = (S)-CHMePh. The chloride ligands of these complexes can be readily replaced by the chelating ligands thiosalicylate and catecholate; the resulting derivatives show markedly higher anti-tumour activity versus P388 murine leukaemia cells compared to the parent chloride complexes. Reaction of (2-Cl2AuC6H4)Ph2P{double bond, long}NPh with PPh3 results in displacement of a chloride ligand giving the cationic complex [(2-Cl(PPh3)AuC6H4)Ph2P{double bond, long}NPh]+, indicating that the P{double bond, long}N donor is strongly bonded to the gold centre.