118068-35-2

Basic information

• Product Name: 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine
• Synonyms: 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine
• CAS NO: 118068-35-2
• Molecular Weight: 719.04
• Mol File: 118068-35-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine(118068-35-2)
• EPA Substance Registry System: 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine(118068-35-2)

Safety Data

• Hazardous Substances Data: 118068-35-2(Hazardous Substances Data)

Upstream product

• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 105930-84-5 tert-butyl(((2R,3S)-3-((tert-butyldiphenylsilyl)oxy)-2,3-dihydrofuran-2-yl)methoxy)diphenylsilane 
• 198267-27-5 1-<3-O-tert-butyldiphenylsilyl-5-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl>thymine 
• 825649-02-3 5-(N-methoxymethylamine)-2'-deoxyuridine 
• 825649-03-4 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-phenylselenylmethyl-2'-deoxyuridine 
• 5116-24-5 2'-deoxy-5-(hydroxymethyl)uridine 
• 118070-23-8 3',5'-di-O-(tert-butyldiphenyl)silyl-α,α-difluorothymidine 
• 118068-38-5 3',5'-di-O-(tert-butyldiphenyl)silyl-α-fluorothymidine 
• 118068-36-3 3',5'-di-O-(tert-butyldiphenyl)silyl-α-hydroxythymidine 
• 118068-37-4 3',5'-di-O-(tert-butyldiphenyl)silyl-2'-deoxy-5-formyluridine 
• 101527-46-2 α,α-difluorothymidine 
• 198267-29-7 1-<5-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2-deoxy-β-D-ribofuranosyl>thymine 
• 50-89-5 thymidine 
• 118070-22-7 3',5'-bis-O-(tert-butyldiphenylsilyl)-5-bromomethyl-2'-deoxyuridine 

Relevant articles and documents

1,3-Dipolar cycloaddition reactions of 3′,5′-Bis-O-silyl thymidines. Synthesis of novel azabicyclic compounds

An efficient one step procedure for the preparation of (4.3.0) bicyclic N-methylpyrrolidine thymidine derivatives 4, using cycloaddition reaction of the highly reactive non-stabilized azomethine ylide [Y] with 3′,5′-Bis-O-silylthymidines 3.

Facile preparation of protected furanoid glycals from thymidine

The synthesis of O-silyl- and O-acyl-protected furanose glycals from free thymidine was investigated. The method of glycal formation reported by Pedersen et al. was successfully expanded to include 5-ester (toluoyl) protected glycals as well as various combinations of 5'-ester and 3- and 5- tert-butyldimethylsilyl and tert-butyldiphenylsilyl protection. Gram quantities of furanoid glycals can be prepared in a few days in two-four steps in overall yields ranging from 17 to 80%.