1181081-71-9

Basic information

• Product Name: (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one
• Synonyms: (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one
• CAS NO: 1181081-71-9
• Molecular Weight: 307.348
• Mol File: 1181081-71-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 473.3±55.0 °C(Predicted)
• Density: 1.50±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one(1181081-71-9)
• EPA Substance Registry System: (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazol-4-one(1181081-71-9)

Safety Data

• Hazardous Substances Data: 1181081-71-9(Hazardous Substances Data)

Usage

Uses

CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.

Biochem/physiol Actions

CLP257 is a selective K+-Cl? cotransporter KCC2 activator that restored impaired Cl? transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

Upstream product

• 1181082-05-2 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 2-oxopyrrolidine-1-carboxylate 
• 1181081-70-8 (5Z)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-2-(methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one 
• 89990-53-4 tetrahydropyridazine dihydrochloride 

Downstream Products

• 1181082-94-9 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl N,N-dimethylcarbamate 
• 1181081-78-6 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl thiomorpholine-4-carboxylate hydrochloride 
• 1181081-83-3 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl piperidine-1-carboxylate hydrochloride 
• 1181083-09-9 (E)-5-fluoro-2-((4-oxo-2-(1,2-diazinan-1-yl)thiazol-5(4H)-ylidene)methyl)phenyl 2-(tert-butoxycarbonylamino)-2-methylpropanoate 
• 1181081-73-1 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl pyrrolidine-1-carboxylate hydrochloride 
• 1181083-13-5 (S,E)-5-fluoro-2-((4-oxo-2-(1,2-diazinan-1-yl)thiazol-5(4H)-ylidenE)methyl)phenyl 2-(tert-butoxycarbonylamino)-4-methylpentanoate 
• 1181082-05-2 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 2-oxopyrrolidine-1-carboxylate 
• 1181082-06-3 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 5-chloro-2,3-dihydro-1H-pyrrole-1-carboxylate 
• 1181222-72-9 methyl 6-(2-{[(5Z)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenoxy)-3,4,5-tris(acetyloxy)oxane-2-carboxylate 
• 1181083-12-4 (R,E)-tert-butyl 2-((5-fluoro-2-((4-oxo-2-(1,2-diazinan-1-yl)thiazol-5(4H)-ylidene)methyl)phenoxy)carbonylamino)-3-methylbutanoate 
• 1181081-93-5 (5Z)-2-(1,2-diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-4,5-dihydro-1,3-thiazole-4-thione 
• 1181082-20-1 2-{[(5Z)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenoxyphosphonic acid 
• 1181081-79-7 2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenyl 1,2-oxazolidine-2-carboxylate hydrochloride 
• 1181082-09-6 methyl 4-[(2-{[(5E)-2-(1,2-diazinan-1-yl)-4-oxo-4,5-dihydro-1,3-thiazol-5-ylidene]methyl}-5-fluorophenoxycarbonyl)amino]butanoate 

Relevant articles and documents

ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS

The present invention relates to Arylmethylidene heterocycles, compositions comprising an Arylmethylidene heterocycle, and methods useful for treating or preventing pain comprising administering an effective amount of an Arylmethylidene heterocycle as dep