1181267-38-8Relevant articles and documents
Preparation method of bilastine key intermediate
-
Paragraph 0036-0039; 0042-0095, (2021/08/25)
The invention belongs to the technical field of drug synthesis, and relates to 2 - (4 - (2 - (4 -ethoxyethyl) 1 - benzo [2 -] imidazol - 1H - yl) piperi d-ethyl) phenyl) -2 -methylpropionate (-1 -), and a -2 - complex and II acid are used as a catalyst to condensation the enolate anion with the compound (16 15) to form a target product II Ni Lewis. The invention aims to provide a short synthetic route. The provided route raw material condition is mild, the yield is high, the tedious building quaternary carbon atom method reported in the traditional process is avoided, and the method is suitable for industrial production.
Preparation method of bilastine
-
Paragraph 0077; 0078, (2020/04/17)
The invention provides a preparation method of bilastine. Specifically the method comprises the following steps: oxidizing 4-hydroxyethyl phenyl methyl tert-butyrate to obtain 4-acetaldehyde phenyl methyl tert-butyrate, and carrying out a reductive aminat
Preparation method and application of bilastine
-
Paragraph 0078-0080; 0085-0087; 0092-0094, (2019/01/14)
The invention provides a preparation method and application of bilastine. Bilastine is prepared by: subjecting methyl 2-methyl-2-{4-[2-(toluene-4-sulfonyloxy)-ethyl]-phenyl}-propionate as an initial material to condensation synthesis with 1-(2-ethoxy-2-et