1181690-72-1 Usage
Description
(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone is a complex organic compound characterized by its unique molecular structure. It belongs to the class of benzoazepine derivatives, which are known for their diverse range of biological activities and potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs targeting specific receptors or enzymes.
Used in the Synthesis of Lorcaserin:
(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone is used as an impurity in the production of Lorcaserin (L469890, HCl), a novel selective 5-HT2C-receptor agonist for the treatment of obesity. Its presence in the synthesis process may affect the efficacy and safety profile of the final drug product.
Used in the Synthesis of Isoquinoline, Isoindoline, and Benzoazepine Amides:
(R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone is also used as a reagent in the synthesis of isoquinoline, isoindoline, and benzoazepine amides. These compounds serve as therapeutic modulators of the histamine H3 receptor, which play a role in various physiological processes and have potential applications in the treatment of various conditions, such as cognitive disorders, sleep-wake regulation, and inflammatory diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1181690-72-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,1,6,9 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1181690-72:
(9*1)+(8*1)+(7*8)+(6*1)+(5*6)+(4*9)+(3*0)+(2*7)+(1*2)=161
161 % 10 = 1
So 1181690-72-1 is a valid CAS Registry Number.
1181690-72-1Relevant articles and documents
MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
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Page/Page column 74-75, (2009/10/18)
Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as excessive daytime sleepiness, narcolepsy, shift-work sleep disorder, drowsiness as a side effect from a medication, maintenance of vigilance to aid in the completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.
