118248-02-5

Basic information

• Product Name: Z-Asp(OBut)-CHN₂
• Synonyms: Z-Asp(OBut)-CHN₂
• CAS NO: 118248-02-5
• Molecular Weight: 347.371
• Mol File: 118248-02-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Z-Asp(OBut)-CHN₂(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Asp(OBut)-CHN₂(118248-02-5)
• EPA Substance Registry System: Z-Asp(OBut)-CHN₂(118248-02-5)

Safety Data

• Hazardous Substances Data: 118248-02-5(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 5545-52-8 Z-D(tBu)-OH 
• 41446-22-4 (S)-3-Benzyloxycarbonylamino-4-isobutoxycarbonyloxy-4-oxo-butyric acid tert-butyl ester 

Downstream Products

• 1402730-11-3 C₁₈H₂₄N₄O₄ 
• 1402729-93-4 C₁₈H₂₂N₂O₅ 
• 1351767-59-3 (S)-5-(2,6-difluorophenoxy)-3-(2-(5-methoxy-1H-indol-1-yl)acetamido)-4-oxopentanoic acid 
• 1351767-71-9 C₂₆H₂₈F₄N₂O₆ 
• 1351767-70-8 C₂₅H₂₅F₅N₂O₅ 
• 1351767-69-5 C₂₅H₂₅BrF₄N₂O₅ 
• 1351767-68-4 C₂₅H₂₅ClF₄N₂O₅ 
• 166388-89-2 C₂₃H₂₅F₂NO₆ 
• 721398-11-4 tert-butyl (3S)-3-amino-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoate 
• 1338471-24-1 C₁₅H₂₁F₂NO₄ 
• 118247-87-3 (tert-Butoxycarbonyl)-L-leucyl-β-homo-L-aspartyl-L-phenylalaninamide 
• 118333-47-4 Boc-Leu-β-homo-Asp(OBut)-D-Phe-NH2 
• 118247-80-6 (Benzyloxycarbonyl)-β-homo-L-aspartic acid α-pentachlorophenyl ester β-tert-butyl ester 
• 118247-86-2 Boc-Leu-β-homo-Asp(OBut)-NHCH2CH2C6H5 

Relevant articles and documents

Synthesis of N-urethane protected α-aminoalkyl-α-cyanomethyl ketones; Application to the synthesis of 3-substituted 5-amino-1H-pyrazole tethered peptidomimetics

The preparation of N-protected amino/peptide α-cyanomethyl ketones through cyanation of the corresponding α-bromomethyl ketones is described. The utility of the resulting α-cyanomethyl ketones in the synthesis of 3-substituted-5-amino-1H-pyrazoles has also been demonstrated. In both steps a wide range of N-protected amino/peptide acids has been employed and the products are obtained in good yield. The enantiomeric purity of both the α-cyanomethyl ketones and pyrazoles were confirmed by chiral HPLC analysis of the corresponding Z-protected d- and l-Ala-OH as model substrates. The synthesis of peptide pyrazolecarboxamides is also delineated. Georg Thieme Verlag Stuttgart · New York.

CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD

The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.

CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD

The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.