118283-56-0Relevant articles and documents
Renin Inhibitors Containing Esters at the P2-Position. Oral Activity in a Derivative of Methyl Aminomalonate
Repine, Joseph,Himmelsbach, Richard J.,Hodges, John C.,Kaltenbronn, James S.,Sircar, Ila,et al.
, p. 1935 - 1943 (1991)
A series of renin inhibitors containing ester side chains at the P2 subsite are potent inhibitors of primate renin.Derivatives containing the diol isostere (ACDMH) at P1-P'1 were the most potent inhibitors.Moderate selectivity for re
